C(h)AR-ting a new course in incurable lymphomas: CAR T cells for mantle cell and follicular lymphomas

Peripheral T-cell lymphomas with a follicular growth pattern are derived from follicular helper T cells (TFH) and may show overlapping features with angioimmunoblastic T-cell lymphomas.

Rare cases of peripheral T-cell lymphomas with follicular growth pattern (PTCL-F) have been recently reported, and their association with t(5;9)(q33;q22) involving ITK and SYK has been suggested. However, the clinicopathologic aspects of PTCL-F are poorly described and the normal cell counterpart of this subgroup of lymphoma is still unknown. Therefore, we analyzed the pathologic, phenotypic, a...

bcl-1, t(11;14), and mantle cell-derived lymphomas.

and T-Cell Lymphomas

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T-Cell Lymphomas

T-cell lymphomas expressing the T-cell receptor (TCR) are uncommon, although their frequency may be underestimated. They show a broad clinicopathological spectrum. Besides precursor T-cell lymphoblastic leukemia/ lymphoma, various post-thymic T-cell neoplasms have been recognized. Among these, hepatosplenic T-cell lymphoma constitutes the prototype of T-cell lymphomas expressing the TCR and was...

KIR3DL2: A New Therapeutic Target for Cutaneous T-Cell Lymphomas?

Classification of cutaneous T-cell lymphomas (CTCL), encompass several subtypes that vary considerably in terms of clinical presentation and prognosis [1]. When mycosis fungoides (MF) is a slowly progressing skin invasion by clonally derived malignant CD4+ T-lymphocytes, Sézary syndrome (SS) is a more aggressive form characterized by the presence of clonal T-cell populations in the skin, lymph ...